infirmity

"a defect in the ear or eye; a defect in timber or iron; a defect of memory or judgment"

"My grandmother taught me how to bake cookies when I was a child. "

"My grandmother's recent ailment required a visit to the doctor. "

"The constant noise from the construction site made it hard to concentrate on my homework. "

"She has had a persistent cough for weeks."

"My sister is very helpful, especially when it comes to organizing things. "

""I need to buy a few things at the grocery store, like milk and bread." "

"Joe was always complaining about the noise made by his neighbours."

"The privilege to hold a weekly market was invaluable for any feudal era burgh."

"In a small number of horses, muscle weakness may progress to paralysis."

"The old man's frailty made it difficult for him to walk to the grocery store. "

"The complicated instructions on the new software difficult me from completing the project on time. "