noun🔗ShareAn amine, C5H9N3, formed by decarboxylation of histidine, that causes dilatation of capillaries, contraction of smooth muscle, and stimulation of gastric acid secretion; it is released during allergic reactions."The itchy rash was caused by the release of histamine in response to the bug bite. "medicinephysiologybiochemistrybiologychemistrysubstancebodyChat with AIVocabulary GamePractice Reading