noun Download 🔗Share An antihistamine and anticholinergic drug that blocks the effect of histamine at H1 receptor sites, relieving allergy symptoms. Diphenhydramine also reduces smooth muscle contraction, increases heart rate, and sedates the user by blocking muscarinic acetylcholine receptors (mAChRs). Examples : "Example Sentence: "I took diphenhydramine last night to help with my allergies, but I felt very drowsy this morning." " medicine compound substance chemistry biochemistry physiology anatomy biology Chat with AIVocabulary GamePractice Reading